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ea0081p272 | Adrenal and Cardiovascular Endocrinology | ECE2022

Characterization of molecular pathway alterations in Cushing’s Syndrome

Vetrivel Sharmilee , Zhang Ru , Khan Ali , Osswald Andrea , Reincke Martin , Sbieria Silviu , Riester Anna

Context: Transcriptomic based characterization of signaling pathways in the adrenals of different subtypes of Cushing’s syndrome.Patients: For preliminary NGS analyses, a total of 27 adrenal samples were used. The cohort consisted of the following patient groups: Cortisol producing adenoma (CPA, n=9), primary bilateral macronodular adrenal hyperplasia (PBMAH, n=10). The adjacent normal adrenal tissue from pheochromocytoma patients ...